We don't think vitamin vapes work, and we don't recommend them. A vitamin or B12 vape is a battery-powered vape with B12 or another vitamin added to the liquid. No published study has measured how much B12 one delivers, the VitaBar, LUVV and HealthVape labels we checked don't say whether their microgram figure is per puff or per device, and FDA has approved no vape to prevent or treat any condition.
Cyclone Pods makes nicotine-free vapes with no vitamins added, so read this as a competitor's take. We call ours vapes, and we make no health claims for them. Several brands below sell theirs as "diffusers," and our guide to whether a vitamin diffuser counts as a vape covers that word. If you need B12, NIH lists tablets, sublingual tablets, injections and a prescription nasal gel spray, and a blood test shows whether you're low.
Do Vitamin Vapes Work?
We don't think so, and we don't think it's a good idea to use one for B12. No published study shows a vitamin vape delivers a useful dose. The studies some sellers point to used medical nebulizers and aerosol equipment in the 1950s and 1960s, not vape pens. Here is what we checked on Nov 12, 2026:
- No published measurement. A 2025 review that champions inhaled nutrients as medicine says so directly: "At present, there are no published data regarding the health benefits or adverse effects of vitamin vapes" (Robinson et al., Biomedicines, PMID 41301881). Our PubMed searches found no such measurement either.
- Labels without a basis. VitaBar's BOOST bar lists 28.1 mcg of B12, LUVV's RISE 24 mcg and HealthVape's BOOST 12 mcg. None says whether that's per puff or per device, and Breathe B12's pages give no microgram figure.
- Heat claims without a test. Three of the four brands we compare say their devices heat the liquid. The two that name a temperature publish no test showing the B12 survives it.
- Warning letters. On Dec. 1, 2021, FDA sent warning letters to five sellers of vapes with health claims, and four of the letters mention B12.
What Is a Vitamin Vape?
A vitamin vape is a disposable or pod device that turns a flavored liquid plus one or more vitamins into an aerosol you draw from a mouthpiece. All four brands we compare below sell a B12 version and say it has no nicotine. VitaBar, HealthVape and LUVV list vegetable glycerin and propylene glycol in the liquid. Breathe B12's product page lists vegetable glycerin, deionized water, flavor and methylcobalamin, with "No Propylene Glycol."
| Brand | Names on its own pages | Heat stated by the brand? |
|---|---|---|
| VitaBar | "B12 Vape | Vitamin B12 Inhaler" (BOOST page title); "Vitamin Inhalers" and "Wellness Pens" (homepage title) | Yes: "warmed at a low temperature to create a breathable vapor" |
| HealthVape | "Vitamin B12 Vape Pen" (BOOST page title); "nicotine-free disposable vape pen" (the description the page gives search engines) | Yes, in its FAQ: "about 240°F or 115°C" |
| LUVV (LUVV Labs) | "B12 Diffuser | Vitamin B12 Inhaler" (RISE page title); "Caffeine Vape Pen" (caffeine collection title) | Yes, in its FAQ: "gently heated to produce a breathable mist" |
| Breathe B12 | "Methylated B12 Diffuser Bar" (product page title) | Not stated |
MELO Labs titles its B12 collection "B12 Vape Pens | Nicotine-Free B12 Diffusers," two names for one product, and its melatonin product page does the same: "MELO Melatonin Vape | Disposable Diffuser." Our guide to melatonin and sleep vapes covers that category. B12 also rides along in caffeine products. VitaBar's ENERGY bar lists both; see our look at caffeine and B12 energy vapes.
Researchers at USC flagged the category in 2019. Four vitamin brands, they wrote, "sell devices that resemble e-cigarettes but claim that they are nicotine-free and that they deliver vitamins and nutrients," and "there is no evidence to date that vitamin delivery through e-cigarettes confers health benefits" (Basáñez et al., American Journal of Public Health, PMID 30649935).
How Much B12 Is in a Vitamin Vape?
Most vitamin vape labels we checked give a B12 number but not a basis. None of the labels below states the B12 in a single puff, and without a basis, a microgram figure can't tell you what you inhale.
One seller outside this table does give a per-puff figure, then contradicts it: purediffuser.com's B12 guide says "Each puff contains approximately 50mcg of Vitamin B12 (cyanocobalamin)," while the description the same page gives search engines says "5000mcg per device," which is 100 times less per puff on a 10,000-puff device. The same guide reports blood results from "a 30-day study with 50 participants using Pure Mate Vitalize," naming no researchers, lab or journal, and we found no record of it in PubMed (searched Nov 12, 2026).
| Product | B12 as listed | Basis stated? | Rated use (brand's words) |
|---|---|---|---|
| VitaBar BOOST (Berry Mint) | "Vitamin B12 (28.1 mcg)" | No | "750-850 inhalations" |
| VitaBar B12 Pods (Berry Mint) | "Vitamin B12 (240 mcg)" | No: per pod or per pack of "2 sealed pods - 2ml each"? | "approx. 1,600 inhalations" per 2-pod pack |
| LUVV RISE (Berry Mint) | "Vitamin B12 (24 mcg)" | No | "650-700 inhalations" |
| HealthVape BOOST (Berry Mint) | "Vitamin B12 (12 mcg)" | No | "450-500 inhalations" |
| Breathe B12 Bar (Mint) | No figure: "Each serving contains many, many times your daily vitamin B12" | No ("serving" isn't defined) | "~5000 puffs" |
Take VitaBar's 28.1 mcg. If that's the whole bar, it works out to about 0.03 to 0.04 mcg per inhalation. If it's per inhalation, one bar holds roughly 21,000 to 24,000 mcg. The two readings are 750 to 850 times apart, and the page doesn't pick one. Even the right reading wouldn't tell you how much reaches your blood.
One seller's dosing advice ended up in an FDA file. The agency's 2021 warning letter to Vitamin Vape, Inc. quotes the company's instructions: "Take 5-10 puffs whenever desired. There is no upper-limit on the amount of B12 you can have in any given day." That letter concerns Vitamin Vape, Inc. only.
Can You Absorb B12 by Inhaling It?
Inhaled B12 was absorbed in 1950s and 1960s studies that used medical nebulizers and aerosol equipment. From a vape, no published study has measured it.
In 1952, doctors in Detroit gave two pernicious-anemia patients B12 in saline "by means of pressure tank and a vaponephrin nebulizer," and a third breathed B12 powder from "a dust inhaler (aerohalor-Abbott)" (Smith, Monto and Rebuck, PMID 13136209). The nebulizer solution held a measured 15 micrograms of B12 per milliliter, which the authors called the dose "usually employed in parenteral administration," meaning injections.
A 1967 study in the British Journal of Haematology gave cyanocobalamin "in the form of an aerosol" and reported "a rapid increase in serum B12 levels." Six patients with pernicious anaemia "given daily inhalations showed complete clinical and haematological remission." The authors still concluded that the method "is not regarded as superior to that of injections and is therefore considered to have no therapeutic application" (Shinton and Singh, PMID 6018215).
The 2025 review is more enthusiastic, and it argues for inhaled "aeronutrient" therapy. Its abstract says inhaled B12 "resolves the symptoms and haematological features of pernicious anaemia with a bioavailability comparable to intramuscular injections" (Robinson et al.; the authors declare no conflicts). That rests on a small base. The review's table of human B12 studies has eight entries: the Detroit report (which the review dates 1953), the 1967 study and six intranasal studies.
The same review draws a line at consumer products. It says aeronutrient therapy "should be regarded as a medical intervention," unlike "the 'vitamin vapes' marketed by the wellness industry."
| Route | Human absorption data? | Example |
|---|---|---|
| Intranasal (spray or gel) | Yes | 750 and 1,500 mcg hydroxocobalamin in 10 healthy older adults: absorption "rapid, high and well tolerated" (van Asselt et al., 1998, PMID 9489599) |
| Inhaled B12 from medical equipment | Yes, from small studies, 1952 to 1967 | The Detroit nebulizer and dust-inhaler patients (1952) and the 1967 aerosol study, both above |
| Vitamin vape | None published | VitaBar, LUVV, HealthVape and Breathe B12 give no per-puff microgram figure |
Sellers lean on that history anyway. FDA's letter quotes Vitamin Vape, Inc.: "the inhalation science goes back a half century." It does, and that science is the Detroit nebulizer and the 1967 aerosol, not a vape. In 2018, the Electronic Retailing Self-Regulation Program, now part of BBB National Programs, reviewed three inhalation studies submitted for VitaminVape's B12 vaporizer. The program said it "was concerned about the relevancy of these studies" because, among other reasons, "the studies did not administer vitamin B12 through a vaporizer similar to VitaminVape."
MELO's B12 page says "Inhaled vitamin B12 is absorbed through the lung tissue," yet MELO's own blog says vitamin vapes haven't been "shown to deliver nutrition reliably" and advises, "If nutrition is the goal, stick with food or an established supplement route." VitaBar, HealthVape and LUVV name a different route: the mouth, nose and throat. None of the four brands we compare shows blood data on the product and FAQ pages we checked on Nov 12, 2026.
Does Heat Break Down B12?
Heat can break down B12 in lab tests. Inside a vape, no published study has tested it. HealthVape says it warms the liquid "to maintain the integrity of the vitamins and supplements - about 240°F or 115°C." LUVV gives the same figure: "Approximately 240°F (115°C), which helps preserve vitamin integrity." Neither had published a test showing the B12 survives when we checked their sites on Nov 12, 2026. VitaBar says only that its liquid is "warmed at a low temperature," and Breathe B12 doesn't say whether its bar heats at all.
In solution, an hour at 100 °C cost 38% of cyanocobalamin, 34% of hydroxocobalamin and 38% of methylcobalamin (Hadinata Lie et al., 2020, PMID 30932778, as summarized in a 2022 review, PMID 36615431). That review calls B12 "susceptible to photolytic, hydrolytic, oxidative, and thermal degradation." A puff lasts seconds, though, and the review notes that methylcobalamin held up after 20 minutes at 100 °C in the dark. The brands' "integrity" lines rest on no published data.
What Has FDA Said About B12 Vapes?
FDA's consumer page says no vaping product is approved to prevent or treat any health condition. That's true of every vape, ours included. FDA's page frames its letters around "unproven health claims," and all five below are dated Dec. 1, 2021.
| Recipient | Letter (MARCS-CMS) | Products FDA named | B12 in the letter? |
|---|---|---|---|
| Vitamin Vape, Inc. | 617787 | "B 12 VITAMINVAPE" | Yes, a B12 product |
| NV Nutrition, LLC | 617979 | "nutrovape vaporizer products and nutriair diffuser products" | Yes, quotes a B-12 claim |
| Eagle Energy USA, Inc. | 617712 | "Caffeine Pen" | Yes, in the quoted formula |
| VitaStik, Inc. | 617713 | "VitaStik" products | Yes, in a melatonin product's description |
| VitaCig, Inc. | 617847 | "VitaCig" products | No |
In the Vitamin Vape, Inc. letter, FDA noted the product carried a Nutrition Facts label but "does not meet the definition of 'food,'" and called it an "unapproved new drug." None of the five letters names VitaBar, Breathe B12, HealthVape or LUVV. We searched FDA's warning-letter database on Nov 12, 2026 and found no later letter about a vitamin or B12 inhaler.
Two sellers we checked describe their regulatory status in their own words, shown here beside FDA's. FDA's letters went to other companies (none of the five letters names Clenzy or MELO), and we're not drawing a legal conclusion.
| Seller | What the seller says | What FDA has said |
|---|---|---|
| Clenzy (Vitamin Vapor product page) | An "FDA Approved" badge, and in its FAQ: "Yes, Clenzy is FDA approved" | "Currently, no vaping products are approved by the FDA to prevent or treat any health conditions or diseases." (consumer page on the Dec. 2021 letters) |
| MELO Labs (HELOMELO FAQ; a near-identical answer appears on its HELO B12 diffuser product page) | "HELOMELO is a dietary supplement, so there are currently no provisions that require FDA approval." | To NV Nutrition and Eagle Energy (Dec. 1, 2021): their inhaled products "are not intended for ingestion" and therefore "do not meet the definition of a dietary supplement under the FD&C Act." |
Which Vitamin B12 Vape Is the Best?
None that we'd recommend. We don't think they're good products for getting B12: the brands below give no per-puff microgram figure and show no blood data, and the studies that found inhaled B12 was absorbed used medical nebulizers and aerosol equipment, not vape pens. We haven't used these devices, so everything here comes from the brands' own pages, checked Nov 12, 2026. For one of them in depth, read a full review of HealthVape.
| Product | Heat stated? | Blood data shown? | Price (single) | Cost per 1,000 rated puffs |
|---|---|---|---|---|
| VitaBar BOOST | Yes | No | $19.99 | $23.52–$26.65 |
| VitaBar B12 Pods | Yes (VitaBar FAQ) | No | $24.99 for 2 pods | $15.62, plus the VitaBar battery the pods need |
| LUVV RISE | Yes | No | $19.99 | $28.56–$30.75 |
| HealthVape BOOST | Yes | No | $19.99 | $39.98–$44.42 |
| Breathe B12 Bar | Not stated | No | $25.00 | $5.00 |
What Is VitaBar?
VitaBar sells disposable "Vitamin Inhalers" and refill pods, and its BOOST page is titled "B12 Vape." A BOOST bar costs $19.99, and VitaBar says it "should last between 750-850 inhalations." Its B12 pods list "Vitamin B12 (240 mcg)" and need VitaBar's rechargeable battery.
We don't think it works as a way to get B12. VitaBar lists "Vitamin B12 (28.1 mcg)" for its BOOST bar without saying whether that's per puff or per device. Its label does give microgram amounts for B12 and four other actives (B6, L-theanine, L-lysine and taurine), which Breathe B12's doesn't. VitaBar shows no blood data for its "mucus membranes" absorption claim.
What Is Breathe B12?
Breathe B12's FAQ makes a dose claim with no microgram figure behind it: "5-10 breaths is approximately 5,000%+ of your Daily Value." The Daily Value for B12 is 2.4 mcg, so that implies 120 mcg or more in 5 to 10 breaths, roughly 12 to 24 mcg a breath. Breathe's site shows no measurement behind the percentage, and we wouldn't trust that number without one.
The product is a "Methylated B12 Diffuser Bar" rated at about 5,000 puffs for $25, with a USB-C rechargeable battery, and Breathe doesn't say whether it heats. In its favor, it lists its ingredients, and its footer says "Breathe expressly makes no health or medical claims for this product."
What's a Better Way to Get B12?
Find out whether you need it first. "Most people in the United States consume adequate amounts of vitamin B12," says NIH's Office of Dietary Supplements, and a blood test shows where you stand. If you do need it, ODS lists tablets, sublingual tablets ("no difference in efficacy between oral and sublingual forms"), a prescription nasal gel spray, and injections, which are the usual treatment for deficiency and pernicious anemia. A 2018 Cochrane review found high-dose oral B12 about as good as injections at normalizing blood levels, on low-quality evidence (PMID 29543316). Ask your doctor which fits you.
What's in Our Vapes?
Gust Pro, Gust Core and Lightning use USP-grade vegetable glycerin and propylene glycol with food-grade flavorings. We add no vitamins, and we make no health claims for them. Legend Technical Services' results for each Gust Pro and Lightning flavor tested so far, trace findings included, are in our per-flavor Gust Pro and Lightning reports.
Want Flavor Without a Functional Ingredient?
Then skip the vitamin and buy a vape that says it's a vape. Gust Pro is rated 20,000 puffs for $20, Gust Core 50,000 puffs for $25 and assembled in the USA, and a Lightning pod 10,000 puffs for $14.
| Device | Rated use | Price (single) | Cost per 1,000 rated puffs | B12 listed |
|---|---|---|---|---|
| Gust Core | 50,000 puffs | $25 | $0.50 | None |
| Gust Pro | 20,000 puffs | $20 | $1.00 | None |
| Lightning pod | 10,000 puffs | $14 ($20 starter kit) | $1.40 | None |
That's $0.50 to $1.40 per 1,000 rated puffs, against $5.00 to $44.42 for the B12 vapes in the comparison table above. If you'd rather swap pods than buy a new device, Lightning's 7ml flavor pods attach magnetically to a rechargeable battery. Not sure which fits? See which of our three devices suits you, or browse every vape in our nicotine-free collection.
